Enzymatic Oxidation of Methyl Groups on Aromatic Heterocycles: A Versatile Method for the Preparation of Heteroaromatic Carboxylic Acids | Zendy

Kiener Andreas | Zendy

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Enzymatic Oxidation of Methyl Groups on Aromatic Heterocycles: A Versatile Method for the Preparation of Heteroaromatic Carboxylic Acids

Author(s) -

Kiener Andreas

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199207741

Subject(s) - chemistry , pseudomonas putida , pyrazine , thiophene , pyrrole , pyridine , organic chemistry , furan , yield (engineering) , carboxylic acid , pyrazole , enzyme , materials science , metallurgy

Heteroarenes such as pyrrole, pyrazole, furan, thiophene, pyridine, and pyrazine substituted by one or more methyl groups can be oxidized to the corresponding monocarboxylic acids by the bacterial strain Pseudomonas putida ATCC 33015 grown on para ‐xylene. Within 50 h on a 20 L scale, 20 gL −1 of 2,5‐dimethyl‐pyrazine ( 1 ) could be converted in quantitative yield to 5‐methylpyrazine‐2‐carboxylic acid (as the sodium salt 2 ).

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