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Enantioselective Synthesis of 3‐Substituted 2‐Ketoesters
Author(s) -
Enders Dieter,
Dyker Hubert,
Raabe Gerhard
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199206181
Subject(s) - enantioselective synthesis , electrophile , enantiomer , alkyl , chemistry , hydrazone , stereochemistry , halide , combinatorial chemistry , organic chemistry , catalysis
An enzyme‐mimetic transfer of the unit 1 (homologous to pyruvate) to electrophiles such as alkyl halides makes the SAMP–/RAMP–hydrazone method possible. With this technique the 3‐substituted 2‐ketoesters, ( S )‐ or ( R )‐ 2 , are accessible in high enantiomeric excesses.