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Synthesis of Octameric Phosphodiesters of [3,3‐Bis(hydroxymethyl)cyclobutyl]adenine and ‐Thymine as well as their Hybridization Properties
Author(s) -
Henlin JeanMichel,
Jaekel Klaus,
Moser Peter,
Rink Hans,
Spieser Erich,
Baschang Gerhard
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199204821
Subject(s) - deoxyribose , nucleic acid , thymine , chemistry , ribose , stereochemistry , hydroxymethyl , biochemistry , rna , dna , enzyme , gene
The concept of antisense nucleic acids promises the possibility of specific interventions in the nucleic acid metabolism. Apart from the direct derivatives of ribose and deoxyribose, no structures that pair with RNA in the form of oligomeric phosphodiesters are known so far. The first examples, obtained from the carbanucleoside 1 , namely octanucleotides of the type 2 (B = thymine, adenine), are reported here.