Tris(cyclopentanolato)oxovanadium( V ): a Model for the Transition State of Enzymatic Phosphoester Cleavage | Zendy

Hillerns Frank | Zendy; Olbrich Falk | Zendy; Behrens Ulrich | Zendy; Rehder Dieter | Zendy

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Tris(cyclopentanolato)oxovanadium( V ): a Model for the Transition State of Enzymatic Phosphoester Cleavage

Author(s) -

Hillerns Frank,

Olbrich Falk,

Behrens Ulrich,

Rehder Dieter

Publication year - 1992

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199204471

Subject(s) - cleavage (geology) , phosphodiester bond , tris , enzyme , chemistry , stereochemistry , enzymatic hydrolysis , biochemistry , biology , rna , fracture (geology) , gene , paleontology

Vanadium atoms with distorted trigonalbipyrimidal coordination are found in dimer 1 ; the oxo ligand of one monomeric unit and a bridged O atom of an alkoxy ligand of the second form the apexes of the bipyramid. The enzymatic cleavage of phosphate esters, which is presumed to proceed via a transition state with a pentavalent phosphorus atom, can be inhibited by vanadates. Complexes like 1 may serve as model compounds for this transition state.

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