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Tris(cyclopentanolato)oxovanadium( V ): a Model for the Transition State of Enzymatic Phosphoester Cleavage
Author(s) -
Hillerns Frank,
Olbrich Falk,
Behrens Ulrich,
Rehder Dieter
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199204471
Subject(s) - cleavage (geology) , phosphodiester bond , tris , enzyme , chemistry , stereochemistry , enzymatic hydrolysis , biochemistry , biology , rna , fracture (geology) , gene , paleontology
Vanadium atoms with distorted trigonalbipyrimidal coordination are found in dimer 1 ; the oxo ligand of one monomeric unit and a bridged O atom of an alkoxy ligand of the second form the apexes of the bipyramid. The enzymatic cleavage of phosphate esters, which is presumed to proceed via a transition state with a pentavalent phosphorus atom, can be inhibited by vanadates. Complexes like 1 may serve as model compounds for this transition state.