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New Chiral α‐Benzyloxyacryliron( II ) Complex for Asymmetric Synthesis of α, α‐Dialkyl‐α‐hydroxycarbonyl Compounds
Author(s) -
Stolz Felix,
Strazewski Peter,
Tamm Christoph,
Neuburger Markus,
Zehnder Margareta
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199201931
Subject(s) - hydrogenolysis , enantiomer , chemistry , chirality (physics) , stereospecificity , stereochemistry , alkylation , cleavage (geology) , catalysis , organic chemistry , chiral symmetry , materials science , physics , quantum mechanics , fracture (geology) , nambu–jona lasinio model , composite material , quark
From simple achiral starting materials the chiral organoiron( II ) complex 1 can be prepared as either the R or S enantiomer. A Michael addition and subsequent stereospecific alkylation followed by oxidative cleavage of the Fe complex fragment and hydrogenolysis of the O ‐benzyl function yields the α,α‐dialkyl‐α‐hydroxycarbonyl compounds with the desired chirality.