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Activation Parameters and Stereochemistry of an Antibody‐Catalyzed Claisen Rearrangement
Author(s) -
Jackson David Y.,
Liang Michael N.,
Bartlett Paul A.,
Schultz Peter G.
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199201821
Subject(s) - catalysis , chemistry , antibody , stereochemistry , combinatorial chemistry , biology , biochemistry , immunology
The catalysis of the same reaction through different mechanisms was attributed to the diversity of the immune response. The chorismate–prephenate conversion 1 → 3 can be catalyzed by antibodies raised against an analogue of the transition state 2 . These antibodies give rise to a variety of activation parameters for the catalysis. An extremely low activation entropy was found for the antibody 11F1‐2E11, which supports the notion that conformational restriction may play an important role in antibody catalysis.