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One‐Pot Synthesis of Tagatose 1,6‐Bisphosphate by Diastereoselective Enzymatic Aldol Addition
Author(s) -
Fessner WolfDieter,
Eyrisch Oliver
Publication year - 1992
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199200561
Subject(s) - aldolase a , dihydroxyacetone phosphate , aldol reaction , chemistry , epimer , fructose bisphosphate aldolase , enzyme , metabolite , dihydroxyacetone , aldolase b , stereochemistry , carbohydrate , biochemistry , organic chemistry , catalysis , glycerol
A new aldolase from E. coli , the D ‐tagatose‐1,6‐bisphosphate‐aldolase (TagA), catalyzes the asymmetric addition of dihydroxyacetone phosphate to D ‐glycerinaldehyde‐3‐phos‐phate, which can be used for the efficient synthesis of the bisphosphate 1 of the rare carbohydrate metabolite D ‐tagatose. A 4‐epimer formed as a byproduct in small amounts can be removed easily from the mixture of products by subsequent specific enzymatic reactions.