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4‐Acyl‐2,3,4,5‐tetrahydro‐2‐methyl‐2,5‐methanobenz‐1,4‐oxazepine, Derivatives of a New Heterocycle
Author(s) -
Kabbe HansJoachim,
Heitzer Helmut,
Born Liborius
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199117091
Subject(s) - ring (chemistry) , conformational isomerism , benzene , solid state , crystallization , chemistry , nitrogen , stereochemistry , medicinal chemistry , organic chemistry , molecule
Two rotamers that are stable in the solid state can be isolated separately for the heterocycle 1. Variation of the crystallization method provides the two modifications that differ in the orientation of the carbonyl group on nitrogen: the CO group points either towards the benzene ring (depicted right) or away from it.