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Diastereomer Separation by Formation of Inclusion Compounds: 2,6‐Dimethylnaphthalene Complexes of Flumethrin
Author(s) -
Born Liborius,
Fuchs Ruiner
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199116341
Subject(s) - diastereomer , adduct , chemistry , inclusion (mineral) , acceptor , stereochemistry , combinatorial chemistry , organic chemistry , mineralogy , physics , condensed matter physics
The separation of the inactive flumethrin isomer from a technical mixture of this insecticide and acaricide was achieved by forming an inclusion complex. The composition of the commercial formulation can thus be enriched in the active diastereomer and dosages can be reduced. X‐ray crystallography reveals that adducts of type 1 are formed. Electron donor–acceptor interactions are probably the controlling factor in the formation of 1 .