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Directed Synthesis of Peptides from α‐Amino Acid Esters at Metal Centers
Author(s) -
Beck Wolfgang,
Krämer Roland
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199114671
Subject(s) - racemization , tripeptide , chemistry , amino acid , reagent , peptide , chelation , peptide synthesis , dipeptide , leucine , metal , stereochemistry , base (topology) , combinatorial chemistry , organic chemistry , biochemistry , mathematical analysis , mathematics
Peptide esters coordinated in a chelate fashion as in 1 (M = Rh, R = Me) may be extended on the amino ends by reaction with α‐amino acid esters in the presence of base. In the case of L ‐leucine methyl ester the resulting tripeptide ester can be cleaved from the metal center with virtually no racemization. The organometallic reagent [{(C 5 Me 5 )RhCl 2 } 2 ] can be recovered.