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6‐Deoxy‐6‐ N ‐histamino‐β‐cyclodextrin Copper( II ) Complex, a New Enantioselective Receptor for Aromatic Amino Acids
Author(s) -
Impellizzeri Giuseppe,
Maccarrone Giuseppe,
Rizzarelli Enrico,
Vecchio Graziella,
Corradini Roberto,
Marchelli Rosangela
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199113481
Subject(s) - enantioselective synthesis , cyclodextrin , chemistry , copper , stereochemistry , organic chemistry , catalysis
Chiral recognition of D ‐ and L ‐tryptophan in the mobile phase in the presence of the title complex [CuL] 2⊕ is the reason for their successful HPLC separation on a conventional achiral reversed‐phase column. The separation is based on mixed inclusion–ligand‐exchange chromatography, in which the more stable complex [CuL( D ‐Trp)] ⊕ probably has the form shown here.