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Amino‐substituted ß‐Benzyl‐ C ‐glycosides; Novel ß‐Glycosidase Inhibitors
Author(s) -
Schmidt Richard R.,
Dietrich Hansjörg
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199113281
Subject(s) - glycoside hydrolase , glycoside , chemistry , stereochemistry , enzyme , biochemistry
Deoxy and amino substituted benzyl‐ C ‐glucosides were prepared and their properties as β‐glucosidase inhibitors were studied. Compound 1 proved to be an efficient competitive inhibitor ( K i = 7.0 × 10 −5 M), with an activity comparable with that of deoxynojirimycin.