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Chemoenzymatic Syntheses of ω‐Ureido D ‐Amino Acids
Author(s) -
Drauz Karlheinz,
Kottenhahn Matthias,
Makryaleas Kyriakos,
Klenk Herbert,
Bernd Michael
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199107121
Subject(s) - amino acid , cleavage (geology) , chemistry , agrobacterium , citrulline , stereochemistry , side chain , biochemistry , combinatorial chemistry , organic chemistry , arginine , transformation (genetics) , biology , polymer , paleontology , fracture (geology) , gene
D‐Amino acids can be prepared chemoenzymatically in very high yields with high enantioselectivity by cleavage of the corresponding hydantoins with Agrobacterium radiobacter bacterial culture. Hydantoins with highly functionalized side chains are also accepted. The synthetic concept is discussed taking D ‐citrulline ( 1 ) as example.