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Synthesis of β,γ‐Unsaturated D ‐α‐Amino Acids from L ‐Cysteine
Author(s) -
Duthaler Rudolf O.
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199107051
Subject(s) - cysteine , hydrolysis , amino acid , chemistry , stereochemistry , organic chemistry , biochemistry , enzyme
D ‐α‐Amino acids 2 are accessible in high optical purity by acid hydrolysis of the 5‐thiazolidinone 1 . Compounds of the type 1 can be prepared in a few reaction steps from L ‐cysteine; during the conversion of 1 into 2 unsaturated residues R remain intact. Boc = tert ‐butoxycarbonyl.