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Biogenesis of the Carbon Skeleton of Glycerinopyrin: A New Biosynthetic Pathway for Pyrroles
Author(s) -
Schönewolf Monika,
Rohr Jürgen
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199101831
Subject(s) - biogenesis , chemistry , carbon skeleton , ring (chemistry) , ant , biosynthesis , stereochemistry , biochemistry , amino acid , leucine , biology , organic chemistry , gene , ecology
Ring closure of the amino acid leucine 1 and its esterification with glycerol 2 embodies a novel biogenesis of the naturally occurring glycerinopyrin 3 . Such a methyl‐substituted fivemembered nitrogen heterocycle occurs otherwise in nature only without the N‐hydroxyl group in an ant phermone and might be formed in this way. The novel biosynthetic pathway to the pyrroles, the “Pigments of Life”, is of great biochemical interest.