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β‐Lithio Ketone Enolates: Generation and Reactions with Electrophiles
Author(s) -
Nakahira Hiroyuki,
Ryu Ilhyong,
Ikrbe Masanobu,
Kambe Nobuaki,
Sonoda Noboru
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199101771
Subject(s) - electrophile , ketone , deprotonation , chemistry , medicinal chemistry , organic chemistry , catalysis , ion
Deprotonation and Sn/Li exchange transforms the ketone 1 into the title compound 2 , which proves to be a most useful synthesis step. The α,β‐dianions of ketones react with electrophiles, whereby two different electrophiles can react sequentially.