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Efficient Stereoselective Total Synthesis of Denticulatins A and B
Author(s) -
Andersen Marc W.,
Hildebrandt Bernhard,
Hoffmann Reinhard W.
Publication year - 1991
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199100971
Subject(s) - stereoselectivity , stereocenter , aldehyde , stereochemistry , chemistry , organic chemistry , enantioselective synthesis , catalysis
Five of the eight stereocenters of the denticulatin 1 were formed by stereoselective aldehyde allylboration. This approach allows an efficient synthesis of even complex molecules. Naturally occurring denticulatin is produced by Siphonaria , which are native to the tidal zones of the Indian Ocean and the Caribbean.
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