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A Novel Type of Ring Contraction as Non‐Enzymatic Step in the Later Stages of the Biosynthesis of Urdamycin H
Author(s) -
Rohr Jürgen
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199010511
Subject(s) - decarboxylation , intramolecular force , ring (chemistry) , chemistry , biosynthesis , contraction (grammar) , oxidative phosphorylation , stereochemistry , enzyme , oxidative decarboxylation , lactone , closure (psychology) , biochemistry , catalysis , organic chemistry , biology , endocrinology , economics , market economy
Intramolecular ring closure and oxidative decarboxylation following lactone ring opening allow urdamycin H ( 2 ) to be synthesized from urdamycin C ( 1 ) in a nonenzymatic process. This was the result of biosynthetic studies and model reactions on the urdamycin system.