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Peptide Synthesis under High Pressure
Author(s) -
Gante Joachim,
Kalthof Ulrike,
Klärner FrankGerrit,
Weber Thomas
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199010251
Subject(s) - amine gas treating , alkyl , amino acid , chemistry , peptide , high pressure , peptide synthesis , organic chemistry , combinatorial chemistry , biochemistry , thermodynamics , physics
Nonactivated amino acid alkyl esters (as ester components) and amino acid Na salts (as amine components) form dipeptides at room temperature under pressures of 7 and 11 kbar [Eq. (a)]. The advantages of this method include the use of inexpensive, readily accessible starting materials and the easy separation of byproducts (alcohols).