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Hydrogenobyrinic Acid: Isolation, Biosynthesis, and Function
Author(s) -
Blanche Francis,
Thibaut Denis,
Frechet Denise,
Vuilhorgne Marc,
Crouzet Joel,
Cameron Béatrice,
Hlineny Kersten,
TraubEberhard Ute,
Zboron Maureen,
Müller Gerhard
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199008841
Subject(s) - biosynthesis , vitamin b12 , function (biology) , biochemistry , isolation (microbiology) , chemistry , biology , bioinformatics , enzyme , genetics
The cobalt‐free analogue of the vitamin‐ B 12 parent substance cobyrinic acid 2 , the hydrogenobyrinic acid 1 , has been made available by a biosynthetic method. This opens up new possibilities for studies on the biosynthesis of 1 and 2 as well as on their chemistry. The first investigations on the biosynthesis and function of 1 are reported; and a complete assignment of the 1 H‐ and 13 C‐NMR signals of 1 is given.