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Semisynthetic Rhodomycins: Novel Glycosylation Methods for the Synthesis of Anthracycline Oligosaccharides
Author(s) -
Kolar Cenek,
Kneissl Günther
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199008091
Subject(s) - glycosylation , trisaccharide , oligosaccharide , chemistry , anthracycline , computational biology , biochemistry , stereochemistry , combinatorial chemistry , biology , genetics , cancer , breast cancer
Anthracyclines, as well as numerous microbial and plant natural products , contain oligosaccharide sequences with α‐linked oligodeoxy sugars as building blocks. New, efficient methods of glycosylation make it possible to prepare α(1→4)‐linked di‐ and trisaccharide partial sequences 1 and 2 of anthracyclines (n = 1,2). These sequences were previously only accessible with difficulty.