Semisynthetic Rhodomycins: Novel Glycosylation Methods for the Synthesis of Anthracycline Oligosaccharides | Zendy

Kolar Cenek | Zendy; Kneissl Günther | Zendy

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Semisynthetic Rhodomycins: Novel Glycosylation Methods for the Synthesis of Anthracycline Oligosaccharides

Author(s) -

Kolar Cenek,

Kneissl Günther

Publication year - 1990

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199008091

Subject(s) - glycosylation , trisaccharide , oligosaccharide , chemistry , anthracycline , computational biology , biochemistry , stereochemistry , combinatorial chemistry , biology , genetics , cancer , breast cancer

Anthracyclines, as well as numerous microbial and plant natural products , contain oligosaccharide sequences with α‐linked oligodeoxy sugars as building blocks. New, efficient methods of glycosylation make it possible to prepare α(1→4)‐linked di‐ and trisaccharide partial sequences 1 and 2 of anthracyclines (n = 1,2). These sequences were previously only accessible with difficulty.

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