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A Novel Pyrrole Synthesis
Author(s) -
Bertschy Hugo,
Meunier Anne,
Neier Reinhard
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199007771
Subject(s) - porphobilinogen , regioselectivity , enol , silylation , pyrrole , alkyl , chemistry , porphobilinogen synthase , biosynthesis , stereochemistry , organic chemistry , dehydratase , catalysis , enzyme
The mechanism for the biosynthesis of porphobilinogen postulated by Shemin can be exploited to synthesize alkyl‐substituted pyrroles such as 3 in a regioselective fashion from silyl enol ethers 1 and protected α‐amino ketones such as 2 .