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Novel Diphosphinoiridium Catalysts for the Enantioselective Hydrogenation of N ‐Arylketimines
Author(s) -
Spindler Felix,
Pugin Benoit,
Blaser HansUlrich
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199005581
Subject(s) - enantioselective synthesis , catalysis , iodide , selectivity , chemistry , asymmetric hydrogenation , organic chemistry , medicinal chemistry
Optical yields as high as 84% ee and turnover numbers up to 10000 are achievable when a catalyst system consisting of [Ir(C 8 H 12 )Cl] 2 , a chiral diphtisphino compound, and iodide is used in the enantioselective hydrogenation of N ‐arylketimines 1 . The anti/syn ratio of the imines has no influence on the selectivity of the hydrogenation.