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Bis( N,N ‐diisopropylamino)trimethylsiloxy‐phosphane: A Novel Flexible Phosphitylating Reagent in Nucleoside Chemistry and Its Application in the Synthesis of P ‐Modified Nucleotides
Author(s) -
Da̧bkowski Wojciech,
Michalski Jan,
Qing Wang
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199005221
Subject(s) - reagent , chemistry , nucleotide , nucleoside , phosphorus , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry , biochemistry , gene
Dinucleotides such as 3, with reactive groups on phosphorus , can be readily prepared starting with the title compound 1 . The first step is.conversion of 1 into the silylphosphites 2 , compounds whose synthetic potential has certainly not yet been exhausted.