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Enantioselective Catalysis with a New Zirconium Trichloride Lewis Acid Containing a “Dibornacyclopentadienyl” Ligand
Author(s) -
Erker Gerhard,
van der Zeijden Adolphus. A. H.
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199005121
Subject(s) - enantioselective synthesis , lewis acids and bases , catalysis , yield (engineering) , zirconium , chemistry , ligand (biochemistry) , camphor , lewis acid catalysis , organic chemistry , medicinal chemistry , materials science , biochemistry , receptor , metallurgy
ee Values in excess of 80% can be achieved in CC coupling reactions of 1‐naphthol with pyruvate esters using the chiral Lewis acid 1 as catalyst. Complex 1 is available from (+)‐camphor via a five‐step synthesis with an overall yield of ca. 30%.