Continuous Generation of NADH from NAD ⊕  and Formate Using a Homogeneous Catalyst with Enhanced Molecular Weight in a Membrane Reactor | Zendy

Steckhan Eberhard | Zendy; Herrmann Sabine | Zendy; Ruppert Romain | Zendy; Thömmes Jörg | Zendy; Wandrey Christian | Zendy

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Continuous Generation of NADH from NAD ⊕ and Formate Using a Homogeneous Catalyst with Enhanced Molecular Weight in a Membrane Reactor

Author(s) -

Steckhan Eberhard,

Herrmann Sabine,

Ruppert Romain,

Thömmes Jörg,

Wandrey Christian

Publication year - 1990

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199003881

Subject(s) - nad+ kinase , formate , catalysis , yield (engineering) , membrane , membrane reactor , formate dehydrogenase , chemistry , cofactor , redox , polyethylene glycol , reactivity (psychology) , materials science , enzyme , organic chemistry , biochemistry , medicine , alternative medicine , pathology , metallurgy

Bonding the Rh III complex 1 to polyethylene glycol (MW 20 000) leads to a high molecular weight redox catalyst suitable for continuous generation of the cofactors NADH and NADPH. With the aid of a newly designed flow‐through membrane reactor it has proven possible to achieve an NAD ⊕ conversion of 40–45% (turnover number 16.9 h −1 , space‐time yield 44.3mmol L −1 d −1 ). Since the reactivity towards polyethylene glycol‐bound NAD ⊕ remains constant, this catalyst is also suited to use in a continuously operating enzyme‐membrane reactor.

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