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Solid‐Phase Synthesis of Glycopeptide Amides under Mild Conditions: Morphiceptin Analogues
Author(s) -
Bardají Eduard,
Torres Josep L.,
Clapés Pere,
Albericio Fernando,
Barany George,
Valencia Gregorio
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199002911
Subject(s) - glycopeptide , glycosidic bond , glycoprotein , chemistry , glycosyl , solid phase synthesis , glycan , phase (matter) , stereochemistry , combinatorial chemistry , biochemistry , peptide , organic chemistry , enzyme , antibiotics
Membrane glycoproteins belong to the most important compounds in living nature. The glycoprotein amides (morphiceptin analogous) have now become readily accessible by a solid‐phase method (glycosyl is galacto‐ or glucopyranosyl). Upon detachment from the carrier, the sensitive glycosidic bond remains intact.