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Combined Chemoenzymatic Synthesis of N ‐Glycoprotein Building Blocks
Author(s) -
Thiem Joachim,
Wiemann Torsten
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199000801
Subject(s) - glycoprotein , galactosyltransferase , chemistry , enzyme , stereochemistry , biochemistry , chemical synthesis , combinatorial chemistry , in vitro
Partial structures of N ‐glycoproteins that are of decisive importance for biological recognition processes on the cellular and molecular level can be prepared by a combination of chemical and enzymatic steps. The aspartyl‐glucosaminyl unit is first synthesized chemically; the subsequent galactosylation to 1 is achieved enzymatically in the presence of galactosyltransferase.