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Elucidation of the Structure of Hormaomycin
Author(s) -
Rössner Ellen,
Zeeck Axel,
König Wilfried A.
Publication year - 1990
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199000641
Subject(s) - chemistry
Hormaomycin is an intercellular signal substance , whose sequence and constitution could be elucidated by a combination of degradation reactions and mass spectrometric and NMR spectroscopic investigations. Hormaomycin is a peptide lactone, which, in addition to containing three known amino acids, allo ‐threonine, isoleucine and (3‐methyl)phenylalanine, also contains two new amino acids: 4‐[( Z )‐propenyl]proline and 3‐(2‐nitrocyclopropylalanine). Signal substances such as 1 are gaining increasing importance for insights into microbial secondary metabolism.