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Formation of 2,4,4‐Trimethylthiete by Photodecarbonylation of 3,3,5‐Trimethyl‐2(3 H )‐thiophenone
Author(s) -
Hinrichs Heiko,
Margaretha Paul
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198914991
Subject(s) - substitution (logic) , chemistry , medicinal chemistry , organic chemistry , computer science , programming language
A very attractive alternative to the hitherto sole entry (Hoffmann elimination of amines) to thiete derivatives such as 1 is provided by the title reaction. It is substantially milder—the thermally not very stable thietes can also be prepared at low temperatures—and enables a broad pattern of substitution. 1 reacts with water to give 4 ‐mercapto‐4‐methylpentan‐2‐one 2 .