A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones | Zendy

Nicolaou K. C. | Zendy; Skokotas G. | Zendy; Maligres P. | Zendy; Zuccarello G. | Zendy; Schweiger E. J. | Zendy; Toshima K. | Zendy; Wendeborn S. | Zendy

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A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones

Author(s) -

Nicolaou K. C.,

Skokotas G.,

Maligres P.,

Zuccarello G.,

Schweiger E. J.,

Toshima K.,

Wendeborn S.

Publication year - 1989

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198912721

Subject(s) - dna , cleavage (geology) , chemistry , stereochemistry , combinatorial chemistry , molecule , sequence (biology) , biochemistry , organic chemistry , biology , paleontology , fracture (geology)

DNA‐cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l – 3 are examples. They are capable of cleaving ϕX174 DNA in a pH‐dependent reaction with maximal activity at pH 8.5.

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