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A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones
Author(s) -
Nicolaou K. C.,
Skokotas G.,
Maligres P.,
Zuccarello G.,
Schweiger E. J.,
Toshima K.,
Wendeborn S.
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198912721
Subject(s) - dna , cleavage (geology) , chemistry , stereochemistry , combinatorial chemistry , molecule , sequence (biology) , biochemistry , organic chemistry , biology , paleontology , fracture (geology)
DNA‐cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l – 3 are examples. They are capable of cleaving ϕX174 DNA in a pH‐dependent reaction with maximal activity at pH 8.5.