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Addition of Carboxamides to Alkynyl Trifluoromethyl Sulfones
Author(s) -
Hanack Michael,
Wilhelm Bärbl
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198910571
Subject(s) - trifluoromethyl , sulfone , sulfoxide , chemistry , triple bond , medicinal chemistry , dimethyl sulfoxide , combinatorial chemistry , organic chemistry , double bond , alkyl
“Push‐pull” compounds 4 are obtained in good yields in an unusual way by addition of carboxamides 2 to the extremely reactive alkynyl trifluoromethyl sulfone 1 . A crucial feature of this reaction is the activation of the triple bond in 1 by the F 3 CSO 2 group. Dimethyl sulfoxide also adds spontaneously to 1 .
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