Premium
A New Synthesis of Key Intermediates for the Preparation of 5,6‐DiHETE and Lipoxin A 4
Author(s) -
Gigou Agnès,
Lellouche JeanPaul,
Beaucourt JeanPierre,
Toupet Loïc,
Grée René
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198907551
Subject(s) - key (lock) , chemistry , organic synthesis , lipoxin , stereochemistry , combinatorial chemistry , biochemistry , biology , catalysis , receptor , ecology
The highly diastereoselective osmylation of a C C bond in proximity to a complex fragment is the key step in the formation of 2 from the butadiene(tricarbonyl)iron complex 1 . The diols 2 can be transformed readily into 3 , key intermediates in the synthesis of 5,6‐DiHETE and lipoxin A 4 . R SiPh 2 t Bu; R′ Me; E CO 2 Me.