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Gas‐Chromatographic Enantiomer Separation of Unfunctionalized Cycloalkanes on Permethylated β‐Cyclodextrin
Author(s) -
Schurig Volker,
Nowotny HansPeter,
Schmalzing Dieter
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198907361
Subject(s) - chemistry , enantiomer , cyclodextrin , chromatography , cyclohexanes , organic chemistry , alkyl , methylcyclohexane , chromatographic separation , amide , high performance liquid chromatography , toluene
In contrast to established procedures for the gas‐chromatographic separation of enantiomers (use of amide phases, complexation gas chromatography), which require the presence of polar functional groups in the compounds being separated, a new procedure now makes it possible to discriminate between the enantiomers of unfunctionalized hydrocarbons. This communication describes the enantiomer separation of cis ‐l‐ethyl‐2‐methylcyclohexane, trans ‐1,1,3,5‐tetramethylcyclohexane, and other alkyl‐substituted cyclohexanes on glass capillary columns containing permethylated β‐cyclodextrin in polysiloxane solution (inclusion mechanism).