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Enantioselective Synthesis of D ‐ threo ‐β‐Hydroxy‐α‐amino Acids with Titanium‐Carbohydrate Complexes
Author(s) -
Bold Guido,
Duthaler Rudolf O.,
Riediker Martin
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198904971
Subject(s) - enantioselective synthesis , glycine , reagent , chemistry , amino acid , carbohydrate , titanium , catalysis , organic chemistry , biochemistry
The addition of the glycine enolate to aldehydes to give the title compounds 2 proceeds with high enantioselectivity and diastereoselectivity, when the titanate 1 is used as chiral template and reagent ( R * , see the two preceding communications). Amino acid esters with free or protected amino groups are readily accessible.