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Enantioselective Aldol Reaction of tert ‐Butyl Acetate using Titanium‐Carbohydrate Complexes
Author(s) -
Duthaler Rudolf O.,
Herold Peter,
Lottenbach Willy,
Oertle Konrad,
Riediker Martin
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198904951
Subject(s) - enantioselective synthesis , aldol reaction , reagent , chemistry , titanium , carbohydrate , organic chemistry , catalysis
The enantioselective transformation of many aldehydes to tert ‐butyl esters of 3‐hydroxycarboxylic acids is possible with the titanium reagent 1 (R * , see preceding communication). Acetate enolates could not be directly used previously. Surprisingly, this aldol reaction is hardly temperature dependent, so that a high induction may also be achieved at room temperature. The reagents (CPTiC1 3 and R * OH) can be recovered.