Enantioselective Aldol Reaction of  tert ‐Butyl Acetate using Titanium‐Carbohydrate Complexes | Zendy

Duthaler Rudolf O. | Zendy; Herold Peter | Zendy; Lottenbach Willy | Zendy; Oertle Konrad | Zendy; Riediker Martin | Zendy

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Enantioselective Aldol Reaction of tert ‐Butyl Acetate using Titanium‐Carbohydrate Complexes

Author(s) -

Duthaler Rudolf O.,

Herold Peter,

Lottenbach Willy,

Oertle Konrad,

Riediker Martin

Publication year - 1989

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198904951

Subject(s) - enantioselective synthesis , aldol reaction , reagent , chemistry , titanium , carbohydrate , organic chemistry , catalysis

The enantioselective transformation of many aldehydes to tert ‐butyl esters of 3‐hydroxycarboxylic acids is possible with the titanium reagent 1 (R * , see preceding communication). Acetate enolates could not be directly used previously. Surprisingly, this aldol reaction is hardly temperature dependent, so that a high induction may also be achieved at room temperature. The reagents (CPTiC1 3 and R * OH) can be recovered.

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