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Discovery of a D ‐Stereospecific Aminopeptidase and Its Use as a Catalyst in Organic Synthesis
Author(s) -
Asano Yasuhisa,
Nakazawa Akiko,
Kato Yasuo,
Kondo Kiyosi
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198904501
Subject(s) - aminopeptidase , stereospecificity , alanine , chemistry , hydrolysis , enzyme , catalysis , stereochemistry , amino acid , biochemistry , leucine
The specific hydrolysis of D ‐amino acid amides and the stereospecifc synthesis of peptides with D ‐alanine‐ N ‐alkylamide residues is made possible by a new aminopeptidase isolated in pure form from cell extracts of Achromobacter sp. SCRC C1‐38. This enzyme, called D ‐alanine aminopeptidase, has a molecular weight of about 122 000 and consists of two identical subunits.