Discovery of a  D ‐Stereospecific Aminopeptidase and Its Use as a Catalyst in Organic Synthesis | Zendy

Asano Yasuhisa | Zendy; Nakazawa Akiko | Zendy; Kato Yasuo | Zendy; Kondo Kiyosi | Zendy

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Discovery of a D ‐Stereospecific Aminopeptidase and Its Use as a Catalyst in Organic Synthesis

Author(s) -

Asano Yasuhisa,

Nakazawa Akiko,

Kato Yasuo,

Kondo Kiyosi

Publication year - 1989

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198904501

Subject(s) - aminopeptidase , stereospecificity , alanine , chemistry , hydrolysis , enzyme , catalysis , stereochemistry , amino acid , biochemistry , leucine

The specific hydrolysis of D ‐amino acid amides and the stereospecifc synthesis of peptides with D ‐alanine‐ N ‐alkylamide residues is made possible by a new aminopeptidase isolated in pure form from cell extracts of Achromobacter sp. SCRC C1‐38. This enzyme, called D ‐alanine aminopeptidase, has a molecular weight of about 122 000 and consists of two identical subunits.

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