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On the Formation of “Free Radicals” from Alkylcobalt Complexes
Author(s) -
Giese Bernd,
Hartung Jens,
He Jianing,
Hüter Ottmar,
Koch Andreas
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198903251
Subject(s) - radical , chemistry , pyridine , reactivity (psychology) , vitamin b12 , photochemistry , cobalt , photodissociation , catalysis , selectivity , medicinal chemistry , organic chemistry , biochemistry , medicine , alternative medicine , pathology
The photolysis of alkylcobaloximes such as 1 affords free radicals. This was deduced from reactivity and selectivity studies in which the intermediates generated from cobaloximes as well as via vitamin B 12 behaved precisely as those from other radical sources. This finding is very important for the planning of syntheses and has implications for the discussions of vitamin B 12 ‐catalyzed reactions in living organisms. Hitherto, the general opinion was that radicals so generated are somewhat stronger bound to the cobalt complex (dmgH 2 = 2,3‐butanedionedioxime, py = pyridine).