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LiBH 4 (NaBH 4 )/Me 3 SiCl, an Unusually Strong and Versatile Reducing Agent
Author(s) -
Giannis Athanassios,
Sandhoff Konrad
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198902181
Subject(s) - reducing agent , chemistry , organic chemistry , amino acid , combinatorial chemistry , biochemistry
Amines can be obtained from amides, nitriles, and nitroalkenes, alcohols from carboxylic acids, and sulfides from sulfoxides in good yields by use of the reducing agent LiBH 4 /Me 3 SiCl. Even α‐amino acids can be easily reduced to amino alcohols with retention of optical purity. Compounds 1 , 3 , and 5 are examples of starting materials; 2 , 4 , and 6 are the products obtained in yields of more than 90%.