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Enantioselective Reduction of α,β‐Unsaturated Carboxylates with NaBH 4 and Catalytic Amounts of Chiral Cobalt Semicorrin Complexes
Author(s) -
Leutenegger Urs,
Madin Andrew,
Pfaltz Andreas
Publication year - 1989
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198900601
Subject(s) - enantioselective synthesis , catalysis , cobalt , chemistry , redox , reaction conditions , reduction (mathematics) , organic chemistry , combinatorial chemistry , mathematics , geometry
High enantioselectivities (up to 96% ee ), almost quantitative chemical yields, and mild reaction conditions characterize the title reaction. It is suitable, for example, for the synthesis of isoprenoid chains as occur in the vitamins E and K 1 . An example is reaction (a), R CH 2 OSiMe 2 t Bu.
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