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Direct Michael Additions of Silyl Groups to α,β‐Unsaturated β‐Arylketones and an α‐Benzylidenelactone with Mixtures Obtained from Copper( I ) Cyanide, Butyllithium and Chlorosilanes
Author(s) -
Amberg Willi,
Seebach Dieter
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198817181
Subject(s) - silylation , reagent , chemistry , alkyl , butyllithium , aryl , michael reaction , cyanide , copper , organic chemistry , medicinal chemistry , addition reaction , catalysis
A considerable simplification of the Michael addition of silyl groups to enones of type 1 was accomplished with the quoted mixture of reagents. The products of type 2 were formed in good yields. 5‐Benzylidene‐2‐ tert ‐butyl‐6‐methyl‐1,3‐dioxan‐4‐one or open‐chain enones with R 1 = H, R 2 = alkyl or aryl have thus far been employed as 1 .