Direct Michael Additions of Silyl Groups to α,β‐Unsaturated β‐Arylketones and an α‐Benzylidenelactone with Mixtures Obtained from Copper( I ) Cyanide, Butyllithium and Chlorosilanes | Zendy

Amberg Willi | Zendy; Seebach Dieter | Zendy

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Direct Michael Additions of Silyl Groups to α,β‐Unsaturated β‐Arylketones and an α‐Benzylidenelactone with Mixtures Obtained from Copper( I ) Cyanide, Butyllithium and Chlorosilanes

Author(s) -

Amberg Willi,

Seebach Dieter

Publication year - 1988

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198817181

Subject(s) - silylation , reagent , chemistry , alkyl , butyllithium , aryl , michael reaction , cyanide , copper , organic chemistry , medicinal chemistry , addition reaction , catalysis

A considerable simplification of the Michael addition of silyl groups to enones of type 1 was accomplished with the quoted mixture of reagents. The products of type 2 were formed in good yields. 5‐Benzylidene‐2‐ tert ‐butyl‐6‐methyl‐1,3‐dioxan‐4‐one or open‐chain enones with R 1 = H, R 2 = alkyl or aryl have thus far been employed as 1 .

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