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Paraformaldehyde as Possible Chirality Amplifier
Author(s) -
Noe Christian R.,
Knollmüller Max,
Ettmayer Peter
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198813791
Subject(s) - paraformaldehyde , chirality (physics) , nucleophile , chemistry , stereochemistry , methylation , physics , organic chemistry , catalysis , biochemistry , quantum mechanics , gene , chiral symmetry breaking , nambu–jona lasinio model , quark
Can enantiomerically pure oligooxymethylene helices induce chirality by means of stereoelectronic effects? This question was investigated by use of the model compounds 1 , n = 1–4. The asymmetric induction—determined by nucleophilic methylation—occurred in the same direction in all cases. This finding indicates that paraformaldehyde may have been involved in the amplification of chirality during the course of chemical evolution.