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Catalytic Syntheses of Functionalized Nitrogen Heterocycles from Cyanogen
Author(s) -
Sundermeyer Jörg,
Roesky Herbert W.
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198813721
Subject(s) - cyanogen bromide , catalysis , oxalyl chloride , cyanogen , chemistry , halide , combinatorial chemistry , nitrogen , organic chemistry , biochemistry , peptide sequence , gene
The synthesis of nitrogen heterocycles such as 1 and 2 from cyanogen and oxalyl halides is possible in one step and in yields of 60–70% with the catalyst system NR 4 ⊕ X ⊖ /HX, X = Cl, Br. Compound 1 can be easily cleaved to give functionalized imidazoles, and 2 is of interest owing to its bactericidal activity as well as its possible use as a synthetic building block.
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