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Enantioselective Catalytic Transfer‐Hydrogenation of α,β‐Unsaturated Carboxylic Acids with Triethylammonium Formate
Author(s) -
Brunner Henri,
Leitner Walter
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198811801
Subject(s) - formic acid , transfer hydrogenation , itaconic acid , enantioselective synthesis , chemistry , formate , rhodium , catalysis , asymmetric hydrogenation , noyori asymmetric hydrogenation , enantiomer , organic chemistry , hydrogen , carboxylic acid , catalytic hydrogenation , ruthenium , polymer , copolymer
Transfer hydrogenation with triethylammonium formate (= formic acid + NEt 3 ) has proven suitable as a method for hydrogenation without molecular hydrogen. In the catalytic hydrogenation of acetylaminocinnamic acid and itaconic acid in the presence of rhodium complexes containing optically active ligands such as (−)‐diop, enantiomeric excesses are achieved which equal or even surpass those of hydrogenation with molecular hydrogen.