A Synthetic Heparin‐like Compound which still Activates Antithrombin III although It Contains an Open Chain Fragment instead of α‐ L ‐Idopyranuronate | Zendy

van Boeckel Constant A. A. | Zendy; Basten Jan E. M. | Zendy; Lucas Hans | Zendy; van Aelst Sjoerd F. | Zendy

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A Synthetic Heparin‐like Compound which still Activates Antithrombin III although It Contains an Open Chain Fragment instead of α‐ L ‐Idopyranuronate

Author(s) -

van Boeckel Constant A. A.,

Basten Jan E. M.,

Lucas Hans,

van Aelst Sjoerd F.

Publication year - 1988

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198811771

Subject(s) - antithrombin , chemistry , heparin , derivative (finance) , coagulation , stereochemistry , glyceric acid , thrombin , fragment (logic) , biochemistry , combinatorial chemistry , catalysis , medicine , immunology , platelet , computer science , financial economics , economics , programming language

Control of the protecting group keyboard was necessary in order to prepare the activated ( R )‐glyceric acid derivative 1 from serine. 1 is the decisive precursor for the synthesis of 2 , a partially opened analogue of the antithrombin III binding region of heparin. 2 likewise catalyzes the antithrombin‐III‐mediated deactivation of the coagulation factor Xa (R = CH 3 , R 2 = SO 3 ⊖ ).

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