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Modified Cyclodextrins—Novel, Highly Enantioselective Stationary Phases for Gas Chromatography
Author(s) -
König Wilfried A.,
Lutz Sabine,
Wenz Gerhard
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198809791
Subject(s) - enantioselective synthesis , enantiomer , gas chromatography , chiral stationary phase , stationary phase , chromatography , cyclodextrin , chemistry , alkylation , organic chemistry , catalysis
Enantiomer separation by gas chromatography in a few minutes and at temperatures between 45 and 130°C is now possible for compounds which cannot form H‐bonds. For peralkylated or partially alkylated and acylated cyclodextrins separation factors of between 1.021 and 1.279 have been achieved. The enantioselectivity of the stationary phase depends—at least partially—on inclusion effects.