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The Cyclopropyl Group in Studies of Enzyme Mechanism and Inhibition
Author(s) -
Suckling Colin J.
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198805371
Subject(s) - cyclopropane , group (periodic table) , chemistry , ring (chemistry) , hydrate , stereochemistry , mechanism (biology) , enzyme , biochemistry , organic chemistry , philosophy , epistemology
The cyclopropyl group—particularly in compounds such as cyclopropylmethanol, phenylcyclopropylamine, and cyclopropanone hydrate—has proved to be very useful in the study of enzyme reactions. Whether the cyclopropane ring is opened to form a radical or remains intact can provide much information about reactions occurring at the active site.