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Synthesis and Properties of N α ‐Di‐ tert ‐Butoxycarbonyl and N α ‐Benzyloxycarbonyl tert ‐Butoxycarbonyl Amino Acids
Author(s) -
Gunnarsson Kerstin,
Grehn Leif,
Ragnarsson Ulf
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198804001
Subject(s) - amino acid , protecting group , chemistry , function (biology) , stereochemistry , group (periodic table) , organic chemistry , biochemistry , biology , alkyl , evolutionary biology
The N ‐protected amino acids 1 and 2 should find universal application ; they are now accessible in good to very good yields. The allyl group has proven to be the best protecting group for the carboxy function. The preparative use of 1 and 2 has been demonstrated by the synthesis of some dipeptides related to Leu‐enkephalin.