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Tris(2,2′‐bipyridyl‐5‐sulfonic acid)rhodium( III ), an Improved Redox Catalyst for the Light‐Induced and the Electrochemically Initiated Enzymatic Reduction of Carbonyl Compounds
Author(s) -
Franke Marlene,
Steckhan Eberhard
Publication year - 1988
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198802651
Subject(s) - chemistry , cyclohexanone , redox , stereospecificity , catalysis , rhodium , nad+ kinase , tris , enzyme , alcohol dehydrogenase , sulfonic acid , medicinal chemistry , photochemistry , polymer chemistry , organic chemistry , biochemistry
Unchanged activity after 36 hours is displayed by the light‐induced redox system consisting of nitrilotriethanol, NAD ⊕ , horse liver alcohol dehydrogenase, cyclohexanone, and [Ru(bpy) 3 ] 2⊕ , with the title compound [Rh(L 3 )] 3⊕ as electron relay. The electrochemically initiated enzymatic reduction of cyclohexanone in an analogous system also takes place with [Rh(L 3 )] 3⊕ as redox catalyst without the formation of inactive (NAD) 2 . Since the reduced form of [Rh(L 3 )] 3⊕ does not reduce carbonyl compounds, it is also possible to exploit fully the stereospecificity of the enzyme with the system described here.