Generation of β‐, γ‐, δ‐, ε‐, and ζ‐Zinc Ketones and Their Transition‐Metal‐Catalyzed Reactions with Carbon Electrophiles | Zendy

Tamaru Yoshinao | Zendy; Ochiai Hirofumi | Zendy; Nakamura Tatsuya | Zendy; Yoshida Zenichi | Zendy

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Generation of β‐, γ‐, δ‐, ε‐, and ζ‐Zinc Ketones and Their Transition‐Metal‐Catalyzed Reactions with Carbon Electrophiles

Author(s) -

Tamaru Yoshinao,

Ochiai Hirofumi,

Nakamura Tatsuya,

Yoshida Zenichi

Publication year - 1987

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198711571

Subject(s) - electrophile , ketone , aryl , zinc , chemistry , catalysis , alkyl , coupling reaction , yield (engineering) , transition metal , medicinal chemistry , metal , organic chemistry , materials science , metallurgy

CC coupling reactions at practically any distance from the carbonyl group of a ketone are made possible by the very stable zinc ketones 1 (X = alkyl, aryl; n = 2–6), which are formed by insertion of Zn into the CI bond of the corresponding iodoketones. The reaction of 1 with electrophiles is exemplified by reaction (a). The yield is 77%.

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